Always scan downloads for viruses, and back up your original memcard first. Now go suplex a Ganado in style.
Double-checking the PCSX2 documentation might be useful to confirm the memory card settings. Also, looking up any Resident Evil 4 specific threads in PCSX2 forums or Reddit to see if there are known save issues. It seems unlikely that there's a widespread problem, but better safe than sorry. resident evil 4 pcsx2 memory card save file best
Resident Evil 4 Save Game Files for PlayStation 2 - GameFAQs Always scan downloads for viruses, and back up
