Some antivirus tools (specifically Bitdefender and older versions of Norton) have false-positive heuristics for RPF files because modding tools try to write to them. Add the entire GTA V folder to your AV exclusion list.
Users searching for this keyword are usually troubleshooting a specific problem. Here are the most frequent errors associated with X64u.rpf : X64u.rpf
: x64u.rpf typically contains specific game data such as textures, models, or script files. or script files.
