On PCSX2, you can boot the Codebreaker .ISO just like a game, select your cheats, and then "Swap Disc" to your game file to apply them.

You're looking for a PS2 ISO download for Codebreaker v10, an exclusive piece of software.

Codebreaker v10 is often distributed as an "exclusive" download because modern versions come pre-loaded with massive libraries—sometimes featuring over 2,000 games with ready-to-use cheats for both PAL and NTSC regions. 2. Seamless Integration with Modern Modding

To get the latest codes, you can download a "CHEATS" file and replace the existing one on your PS2 memory card after the first launch.