Despite the pain, many still cling to ISE 14.7 on Windows 10 because upgrading to Vivado would mean redesigning boards for newer FPGAs — too costly for legacy products.
The simplest fix: do not use the Xilinx cable. Use a Digilent JTAG cable (HS1, HS2, or HS3). Digilent provides a signed or their own Adept drivers that work with ISE 14.7 on Windows 10. Many Spartan-6 boards (like the Nexys 3) have Digilent interfaces built-in.
Prepare the system:
This is the "official" fix from AMD/Xilinx. It bundles ISE within a pre-configured Linux virtual machine that runs on your Windows 10 desktop via Oracle VirtualBox. How it works
Do not simply double-click the installer. Follow these strict guidelines:
The Challenge of Legacy: Running Xilinx ISE 14.7 on Windows 10
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